IMMUNOLOGY textbook. Иммунология + CD на английском языке
IMMUNOLOGY textbook. Иммунология + CD на английском языке
АртикулQ0008123
ISBN978-5-9704-0704-2
ИздательГЭОТАР-Медиа
АвторыХаитов Р.М.
Год2008
К-во страниц256
Переплеттвердый
This textbook submits the modern data on all aspects of structure and functions of the immune system in norm and pathology. The most recent knowledge about innate immunity and the mechanisms of generation of adoptive immunity is presented at the organismic, cellular and molecular genetic levels. The information about the immune cell populations, the structure of immunocyte receptors, the intracellular signaling pathways, major histocompatibility complex, immunity genetic control, immunologic memory is given. The immune deficiencies, allergic and autoimmune diseases are reviewed. The possibility of phenotypic correction of genetically controlled immunity by the immunotropic drugs is shown. The textbook is supplied with the test examination program on CD. The textbook is intended for students, postgraduates, lecturers, practical physicians and scientific researchers engaged in various fields of medicine and biology.
Introduction

PART I

STRUCTURE AND FUNCTION OF THE IMMUNE SYSTEM

Chapter 1. Main concepts

Organism protective systems

The concept of immunity

Definition of "adaptive immunity"

Immune response

Immunocompetent cells

Objectives of immunology

Chapter 2. Components of the immune system

Thymus

Lymph nodes

Spleen

Liver

Lymphoid tissue of mucous and skin

Chapter 3. Mechanisms of innate immunity

Receptors that recognize "nonself"

Signaling through Toll-like receptors (TLR)

Natural killers

The complement system

Phagocytosis

Endogenous antimicrobial peptides

Type I interferons

Factors of innate resistance against infections

Chapter 4. Immune response

Features of adaptive immune response

Stages of immune response

Mechanisms of cell interactions in immune response

Molecules of intercellular adhesion

Cytokines

Chemokines

Receptors for cytokines and chemokines

Immunological memory

Chapter 5. Antibodies. B-lymphocytes

Antigens

Antibodies

Immunoglobulins

Immunoglobulin classes

Immunoglobulin structure

Antigen binding

Immunoglobulin genes

Genes of variable domains

Constant domain genes

Immunoglobulin class (isotype) switching

B-lymphocytes

B-cell antigen receptor (BCR)

Coreceptor complex

B-lymphocyte differentiation

Natural antibodies

Chapter 6. T-lymphocytes

T-cell antigen receptor (TCR)

TCR genes

CD4 and CD8 coreceptor molecules

Signaling from lymphocyte immune receptors

T-lymphocyte differentiation

T-helper subpopulation

Types of immune response

T?? lymphocytes and thymus-independent antigens

Chapter 7. Antigen-presenting cells

Major histocompatibility complex

Genes of MHC complex

MHC transmembrane glycoproteins

Genetic polymorphism

"Peptide Ag - MHC-I" or "Peptide antigen - MHC-II" complexes

Superantigens

Antigen-presenting CD1 molecules

Antigen-presenting cells

Dendritic cells

Interactions between T- and B-lymphocytes

Factors to determine the immune deviation

Type I immune inflammation

Type II immune inflammation

Chapter 8. Effector mechanisms of immunity

Antibody-dependent mechanisms of protection

Complement components

Fc-receptors

Antibody-dependent cellular cytotoxicity

Immediate-type hypersensitivity

Relict properties of antibodies

T-lymphocyte-dependent effector mechanisms

Delayed-type hypersensitivity

Chapter 9. Inhibition of the immune system

Inhibitory receptors

Apoptosis

Suppression of immune response

Immunological tolerance

Transplantation

Transplant rejection

Major histocompatibility complex

Immunologically privileged sites

Immune system and glucocorticoids

PART II

IMMUNE SYSTEM AND PATHOLOGY

Chapter 10. Classification of pathological processes

Immune status

Chapter 11. Primary immune deficiencies

Immunnoglobulin defects

X-linked Bruton's agammaglobulinemia

X-linked agammaglobulinemia with M hyperimmunoglobulinemia

syndrome

General variable immune deficiency

Immunoglobulin A deficiency

T-lymphocyte defects

Severe combined immune deficiencies

Bare lymphocyte syndrome

DiGeorge syndrome

X-linked lymphoproliferative syndrome

Ataxia-telangiectasia

Wiskott-Aldrich syndrome

Phagocytosis defects

Chronic granulomatous disease

Complement system defects

Diseases associated with complement component deficiencies

Deficiency of mannose-binding lectin

Chapter 12. Secondary Immune Deficiencies

Etiologic factors

Chronic fatigue syndrome

Acquired immune deficiency syndrome

Etiology

Clinical manifestation

Laboratory diagnostics

Treatment

Chemotherapy

Treatment of indicative diseases

Pharmaceutical prophylaxis

Immune therapy

Chapter 13. Allergic diseases

Allergens

Terminology

Hypersensitivity reaction types

Allergic rhinitis

Bronchial asthma

Atopic dermatitis

Systemic anaphylaxis

Food allergy

Urticaria and angioneurotic edema

Allergic and non-allergic reactions to drugs

Organ-specific manifestations of the reactions to drugs

Treatment approaches

Algorithm of allergic disease diagnostics and treatment

Chapter 14. Autoimmune diseases

Etiology and pathogenesis

Endocrine glands diseases

Autoimmune hyperthyroidism

Autoimmune goiter

Type 1 diabetes mellitus

Adrenocortical insufficiency

Cushing's disease

Gastrointestinal tract diseases

Gastritis and pernicious anemia

Celiac disease

Inflammatory intestinal diseases

Hepatitis

Autoimmune hepatic diseases

Blood diseases

Autoimmune hemolytic anemia

Drug-induced hemolysis

Neonatal hemolytic disease

Hemolysis in transfusion complications

Idiopathic autoimmune thrombocytopenic purpura

Nervous system diseases with immune inflammation component

Multiple sclerosis

Severe pseudoparalytic myasthenia

Primary systemic vasculitis

Wegener's granulomatosis

Microscopic polyangiitis

Polyarteritis nodosa

Churg-Strauss syndrome

Sch?nlein-Henoch purpura

Giant cell arteritis

Takayasu's arteritis

Kawasaki's disease

Beh?et's disease

Chapter 15. Principles of immunotherapy

Replacement therapy

Immunosuppressive therapy

Immunostimulating therapy

Vaccination

Chapter 16. Epilogue

PART III

APPENDIX

Immunoglobulins

Immunological parameters of blood

CD marker antigens

Therapeutic drugs

Abbreviations
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