Фармакология. Учебное пособие
Фармакология. Учебное пособие
АвторыХаркевич Д.А.
К-во страниц672
The ninth edition of the textbook is revised and supplemented with new information. Modern considerations concerning the bases of pharmacotherapy of certain diseases are being discussed. Mechanisms of drug action are reviewed according to the latest achievements in fundamental pharmacology. The textbook is designed for medical students.


1. Subject and aims of pharmacology. its position among other medical disciplines. Main stages of pharmacology development

2. Creation of new drugs

3. Main sections of pharmacology. Principles of classification of drugs


1. Drug administration routes. absorption

2. Drug distribution in the body. biological barriers. storage

3. Chemical conversions (biotransformation, metabolism) of drugs in the body

4. Routes of drug elimination from the body

5. Local and systemic effects of the drugs. direct and reflex effects. Localization and mechanism of action. drug "targets".Reversible and irreversible actions. selective action

6. Dependence of pharmacotherapeutic action on drug properties and pattern of use

7. Importance of characteristics of the human body and its general condition for the manifestation of the drug effect

8. Main types of drug treatment

9. Main and adverse effect. allergic reactions. Idiosyncrasy. toxic effects

10. General principles of the treatment of acute drug poisoning


Drugs affecting afferent innervation

Chapter 1. Drugs decreasing sensitivity of afferent nerve endings or preventing their excitation

1.1. Anesthetic drugs (local anesthetics)

1.2. Astringents

1.3. Coating drugs

1.4. Adsorbents

Chapter 2. Drugs stimulating afferent nerve endings

2.1. Irritants

B. Drugs affecting efferent innervation

Chapter 3. Drugs affecting cholinergic synapses

3.1. Drugs affecting muscarinic and nicotinic cholinoceptors

3.2. Anticholinesterase drugs

3.3. Drugs affecting muscarinic cholinoceptors

3.4. Drugs affecting nicotinic cholinoceptors

A. Drugs blocking transmission in autonomic ganglia (ganglionic blockers, ganglion blocking agents)

B. Drugs blocking neuromuscular transmission (neuromuscular relaxants or peripheral muscle relaxants)

Chapter 4. Drugs affecting adrenergic synapses

4.1. Drugs stimulating adrenoceptors (adrenomimetics)

4.2. Drugs blocking adrenoceptors (adrenoceptor antagonists)

4.3. Drugs of presynaptic action

C. Drugs regulating the functions of the central nervous system (Chapters 5-12)

Chapter 5. Anesthetic drugs (general anesthetics)

5.1. Drugs for inhalation anesthesia

5.2. Drugs for noninhalation (intravenous) anesthesia

5.3. Combined use of anesthetics

5.4. Combined use of anesthetics with drugs of different pharmacological groups

Chapter 6. Ethyl alcohol

Chapter 7. Hypnotics

7.1. Benzodiazepine receptor agonists

7.2. Hypnotics with narcotic types of action

Chapter 8. Pain-relieving drugs (analgesics)

8.1. Opioid (narcotic) analgesics and their antagonists

8.2. Non-opioids of central action with analgesic activity

8.3. Analgesics with mixed mechanism of action (opioid + non-opioid)

Chapter 9. Antiepileptic drugs

Chapter 10. Antiparkinsonian drugs

Chapter 11. Psychotropic drugs

11.1. Antipsychotic drugs (neuroleptic agents)

11.2. Antidepressants

11.3. Drugs used in manic states

11.4. Anxiolytics (tranquilizers)

11.5. Sedatives

11.6. Psychostimulant drugs

11.7. Nootropic drugs

Chapter 12. Analeptics

D. Drugs regulating functions of organs and systems

Chapter 13. Drugs affecting the function of the respiratory organs

13.1. Respiration stimulants

13.2. Antitussive drugs

13.3. Expectorants

13.4. Drugs used for the treatment of bronchospasm

13.5. Drugs used in acute respiratory failure

Chapter 14. Drugs affecting the cardiovascular system

14.1. Cardiotonic agents

14.2. Drugs used for the treatment of cardiac rhythm disturbances (anti-arrhythmic drugs)

14.3. Drugs used for the treatment of coronary circulation failure

14.4. Drugs used for the treatment of cerebral blood circulation disorders

14.5. Hypotensive drugs (antihypertensive drugs)

14.6. Hypertensive drugs (drugs used for the treatment of arterial hypotension)

14.7. Venotropic (phlebotropic) drugs

Chapter 15. Drugs that affect the function of the digestive organs

15.1. Drugs that affect appetite

15.2. Drugs the affect salivary gland function

15.3. Drugs used for the treatment of gastric gland function disorder

15.4. Gastroprotectors

15.5. Drugs that affect gastric motor activity

15.6. Emetic and antiemetic drugs

15.7. Hepatoprotective drugs

15.8. Cholagogue drugs

15.9. Drugs that induce gallstone dissolution (cholelithiatic drugs)

15.10. Drugs used for the treatment of pancreatic failure

15.11. Drugs that affect intestinal motor activity

Chapter 16. Diuretics

16.1. Diuretics directly affecting the function of the renal tubular epithelium

16.2. Aldosterone antagonists

16.3. Osmotic diuretics

Chapter 17. Drugs affecting myometrium

Chapter 18. Drugs affecting hemopoiesis

18.1. Drugs affecting erythropoiesis

18.2. Drugs affecting leukopoiesis

Chapter 19. Drugs that affect platelet aggregation, blood coagulation and fibrinolysis

19.1. Drugs used for the prevention and treatment of thrombosis

19.2. Drugs that stop bleeding (hemostatics)

E. Drugs that control metabolic processes

Chapter 20. Hormonal drugs

20.1. Hypothalamic and pituitary hormone drugs

20.2. Hormones of the epiphysis and their drugs

20.3. Thyroid hormones and antithyroid drugs. Calcitonin

20.4. Parathyroid gland hormones and their drugs

20.5. Pancreatic hormones, their drugs and synthetic antidiabetic drugs

20.6. Adrenocorticotropic hormones and their drugs (corticosteroids)

20.7. Sex hormones, their drugs and derivatives, synthetic substitutes and antagonists

Chapter 21. Vitamins

21.1. Water-soluble vitamins

21.2. Fat soluble vitamins

Chapter 22. Antiatherosclerotic drugs (drugs used for the treatment of hyperlipoproteinaemia)

Chapter 23. Drugs used for the treatment of obesity

Chapter 24. Drugs used for the treatment and prevention of osteoporosis

Chapter 25. Drugs used for the treatment of gout

Chapter 26. Anti-inflammatory drugs

Chapter 27. Drugs affecting the immune system

27.1. Anti-allergy drugs. immunosuppressants.

27.2. Immunostimulators

Antimicrobial and antiparasitic drugs

Chapter 28. Antiseptics and disinfectants

Chapter 29. Antibacterial chemotherapeutic drugs

29.1. Antibiotics

29.2. Sulphonamides

29.3. Quinolone derivatives

29.4. Synthetic antibacterial agents of various chemical structures

29.5. drugs for the treatment of syphilis (lues)

29.6. Antituberculous drugs

Chapter 30. Antiviral drugs

Chapter 31. Antifungal drugs

Chapter 32. Antiprotozoan drugs

32.1. Drugs used for the treatment and prophylaxis of malaria

32.2. Drugs used for the treatment of amoebiasis

32.3. Drugs used for the treatment of giardiasis

32.4. Drugs used for the treatment of trichomoniasis

32.5. Drugs used for the treatment of toxoplasmosis

32.6. Drugs used for the treatment of balantidiasis

32.7. Drugs used for the treatment of leishmaniasis

32.8. Drugs used for the treatment of trypanosomosis

Chapter 33. Antihelminthic drugs

33.1. Drugs used for the treatment of intestinal helminthiase

33.2. Drugs used for the treatment of extra-intestinal helminthiases

Chapter 34. Antineoplastic (antiblastomic) drugs

34.1. Alkylating agents

34.2. Antimetabolites

34.3. Antibiotics possessing antitumor activity

34.4. Phytogenic compounds with anti-tumor activity

34.5. Hormonal drugs and hormone antagonists used for the treatment of tumors

34.6. Enzymes that are effective for the treatment of tumors

34.7. Cytokines

34.8. Monoclonal antibodies

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